This article outlines the upcoming 2025 ICD-10-CM code updates, which will go live on October 1, 2024, replacing the 2024 code set that sunsets on January 1, 2025. These updates include 252 additions, 36 deletions, and 13 revisions.

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ICD-10-CM 2025 Code Updates

Here is a list of all the codes that were altered:
ActionICD10 CodeCode description
Revised fromA7741Ehrlichiosis chafeensis [E. chafeensis]
Revised toA7741Ehrlichiosis chaffeensis [E.chaffeensis]
AddedC810A
Nodular lymphocyte predominant Hodgkin lymphoma, in remission
AddedC811ANodular sclerosis Hodgkin lymphoma, in remission
AddedC812AMixed cellularity Hodgkin lymphoma, in remission
AddedC813ALymphocyte depleted Hodgkin lymphoma, in remission
AddedC814ALymphocyte-rich Hodgkin lymphoma, in remission
AddedC817AOther Hodgkin lymphoma, in remission
AddedC819AHodgkin lymphoma, unspecified, in remission
AddedC820AFollicular lymphoma grade I, in remission
AddedC821AFollicular lymphoma grade II, in remission
AddedC822AFollicular lymphoma grade III, unspecified, in remission
AddedC823AFollicular lymphoma grade IIIa, in remission
AddedC824AFollicular lymphoma grade IIIb, in remission
AddedC825ADiffuse follicle center lymphoma, in remission
AddedC826ACutaneous follicle center lymphoma, in remission
AddedC828AOther types of follicular lymphoma, in remission
AddedC829AFollicular lymphoma, unspecified, in remission
AddedC830ASmall cell B-cell lymphoma, in remission
AddedC831AMantle cell lymphoma, in remission
DeletedC8339Diffuse large B-cell lymphoma, extranodal and solid organ sites
AddedC83390Primary central nervous system lymphoma
AddedC83398Diffuse large B-cell lymphoma of other extranodal and solid organ sites
AddedC833ADiffuse large B-cell lymphoma, in remission
AddedC835ALymphoblastic (diffuse) lymphoma, in remission
AddedC837ABurkitt lymphoma, in remission
AddedC838AOther non-follicular lymphoma, in remission
AddedC839ANon-follicular (diffuse) lymphoma, unspecified, in remission
AddedC840AMycosis fungoides, in remission
AddedC841ASezary disease, in remission
AddedC844APeripheral T-cell lymphoma, not elsewhere classified, in remission
AddedC846AAnaplastic large cell lymphoma, ALK-positive, in remission
AddedC847Anaplastic large cell lymphoma, ALK-negative, in remission
AddedC849AMature T/NK-cell lymphomas, unspecified, in remission
AddedC84AACutaneous T-cell lymphoma, unspecified, in remission
AddedC84ZAOther mature T/NK-cell lymphomas, in remission
AddedC851AUnspecified B-cell lymphoma, in remission
AddedC852AMediastinal (thymic) large B-cell lymphoma, in remission
AddedC858AOther specified types of non-Hodgkin lymphoma, in remission
AddedC859ANon-Hodgkin lymphoma, unspecified, in remission
DeletedC860Extranodal NK/T-cell lymphoma, nasal type
AddedC8600Extranodal NK/T-cell lymphoma, nasal type not having achieved remission
AddedC8601Extranodal NK/T-cell lymphoma, nasal type, in remission
DeletedC861Hepatosplenic T-cell lymphoma
AddedC8610Hepatosplenic T-cell lymphoma not having achieved remission
AddedC8611Hepatosplenic T-cell lymphoma, in remission
DeletedC862Enteropathy-type (intestinal) T-cell lymphoma
AddedC8620Enteropathy-type (intestinal) T-cell lymphoma not having achieved remission
AddedC8621Enteropathy-type (intestinal) T-cell lymphoma, in remission
Deleted
C863Subcutaneous panniculitis-like T-cell lymphoma
AddedC8630Subcutaneous panniculitis-like T-cell lymphoma not having achieved remission
AddedC8631Subcutaneous panniculitis-like T-cell lymphoma, in remission
DeletedC864Blastic NK-cell lymphoma
AddedC8640Blastic NK-cell lymphoma not having achieved remission
AddedC8641Blastic NK-cell lymphoma, in remission
DeletedC865Angioimmunoblastic T-cell lymphoma
AddedC8650Angioimmunoblastic T-cell lymphoma not having achieved remission
AddedC8651Angioimmunoblastic T-cell lymphoma, in remission
DeletedC866
Primary cutaneous CD30-positive T-cell proliferations
AddedC8660Primary cutaneous CD30-positive T-cell proliferations not having achieved remission
AddedC8661Primary cutaneous CD30-positive T-cell proliferations, in remission
DeletedC880Waldenstrom macroglobulinemia
AddedC8800Waldenstrom macroglobulinemia not having achieved remission
AddedC8801Waldenstrom macroglobulinemia, in remission
DeletedC882Heavy chain disease
AddedC8820Heavy chain disease not having achieved remission
AddedC8821Heavy chain disease, in remission
DeletedC883Immunoproliferative small intestinal disease
AddedC8830Immunoproliferative small intestinal disease not having achieved remission
AddedC8831Immunoproliferative small intestinal disease, in remission
DeletedC884Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
AddedC8840Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission
AddedC8841Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission
DeletedC888
Other malignant immunoproliferative diseases
AddedC8880Other malignant immunoproliferative diseases not having achieved remission
AddedC8881Other malignant immunoproliferative diseases, in remission
DeletedC889Malignant immunoproliferative diseases
AddedC8890Malignant immunoproliferative diseases not having achieved remission
AddedC8891Malignant immunoproliferative diseases, unspecified, in remission
AddedD6103Fanconi anemia
AddedE10A0Type 1 diabetes mellitus, presymptomatic, unspecified
AddedE10A1Type 1 diabetes mellitus, presymptomatic, Stage 1
AddedE10A2Type 1 diabetes mellitus, presymptomatic, Stage 2
AddedE16A1Hypoglycemia level 1
AddedE16A2Hypoglycemia level 2
AddedE16A3Hypoglycemia level 3
DeletedE340Carcinoid syndrome
AddedE3400Carcinoid syndrome, unspecified
AddedE3401Carcinoid heart syndrome
AddedE3409Other carcinoid syndrome
DeletedE668
Other obesity
AddedE66811Obesity, class 1
AddedE66812Obesity, class 2
AddedE66813Obesity, class 3
AddedE6689Other obesity not elsewhere classified
Added
E74820SLC13A5 Citrate Transporter Disorder
AddedE74829Other disorders of citrate metabolism
AddedE8882Obesity due to disruption of MC4R pathway
DeletedF5001Anorexia nervosa, restricting type
AddedF50010Anorexia nervosa, restricting type, mild
AddedF50011Anorexia nervosa, restricting type, moderate
AddedF50012Anorexia nervosa, restricting type, severe
AddedF50013Anorexia nervosa, restricting type, extreme
AddedF50014Anorexia nervosa, restricting type, in remission
AddedF50019Anorexia nervosa, restricting type, unspecified
DeletedF5002Anorexia nervosa, binge eating/purging type
AddedF50020Anorexia nervosa, binge eating/purging type, mild
AddedF50021Anorexia nervosa, binge eating/purging type, moderate
AddedF50022Anorexia nervosa, binge eating/purging type, severe
AddedF50023Anorexia nervosa, binge eating/purging type, extreme
AddedF50024Anorexia nervosa, binge eating/purging type, in remission
AddedF50029Anorexia nervosa, binge eating/purging type, unspecified
DeletedF502Bulimia nervosa
AddedF5020Bulimia nervosa, unspecified
AddedF5021Bulimia nervosa, mild
AddedF5022Bulimia nervosa, moderate
AddedF5023Bulimia nervosa, severe
AddedF5024Bulimia nervosa, extreme
AddedF5025Bulimia nervosa, in remission
Deleted
F5081Binge eating disorder
AddedF50810Binge eating disorder, mild
AddedF50811Binge eating disorder,moderate
AddedF50812Binge eating disorder, severe
AddedF50813Binge eating disorder, extreme
AddedF50814Binge eating disorder, in remission
AddedF50819Binge eating disorder, unspecified
AddedF5083Pica in adults
AddedF5084Rumination disorder in adults
Revised fromF9821Rumination disorder in infancy
Revised toF9821Rumination disorder in infancy and childhood
AddedG40841
KCNQ2-related epilepsy, not intractable, with status epilepticus
AddedG40842KCNQ2-related epilepsy, not intractable, without status epilepticus
AddedG40843KCNQ2-related epilepsy, intractable, with status epilepticus
AddedG40844KCNQ2-related epilepsy, intractable, without status epilepticus
DeletedG908Other disorders of autonomic nervous system
AddedG9081Serotonin syndrome
AddedG9089Other disorders of autonomic nervous system
Revised fromG9342Megaloencephalic leukoencephalopathy with subcortical cysts
Revised toG9342Megalencephalic leukoencephalopathy with subcortical cysts
AddedG9345Developmental and epileptic encephalopathy
Revised fromH442A3Degenerative myopia with choroidal neovascularization, bilateral eye
Revised toH442A3Degenerative myopia with choroidal neovascularization, bilateral
Revised fromH442B3Degenerative myopia with macular hole, bilateral eye
Revised toH442B3Degenerative myopia with macular hole, bilateral
Revised fromH442C3Degenerative myopia with retinal detachment, bilateral eye
Revised toH442C3Degenerative myopia with retinal detachment, bilateral
Revised fromH442D3Degenerative myopia with foveoschisis, bilateral eye
Revised toH442D3Degenerative myopia with foveoschisis, bilateral
Revised fromH442E3Degenerative myopia with with other maculopathy, bilateral eye
Revised toH442E3Degenerative myopia with with other maculopathy, bilateral
AddedI2603Cement embolism of pulmonary artery with acute cor pulmonale
AddedI2604Fat embolism of pulmonary artery with acute cor pulmonale 
Revised fromI2693Single subsegmental pulmonary embolism without acute cor pulmonale
Revised toI2693Single subsegmental thrombotic pulmonary embolism without acute cor pulmonale
Revised fromI2694Multiple subsegmental pulmonary emboli without acute cor pulmonale
Revised toI2694Multiple subsegmental thrombotic pulmonary emboli without acute cor pulmonale
AddedI2695Cement embolism of pulmonary artery without acute cor pulmonale
AddedI2696Fat embolism of pulmonary artery without acute cor pulmonale
AddedJ348200Internal nasal valve collapse, unspecified
AddedJ348201Internal nasal valve collapse, static
AddedJ348202Internal nasal valve collapse, dynamic
AddedJ348210External nasal valve collapse, unspecified
AddedJ348211External nasal valve collapse, static
AddedJ348212External nasal valve collapse, dynamic
AddedJ34829Nasal valve collapse, unspecified
Revised fromK589Irritable bowel syndrome without diarrhea
Revised toK589Irritable bowel syndrome, unspecified
DeletedK603Anal fistula
AddedK6030Anal fistula, unspecified
AddedK60311Anal fistula, simple, initial
AddedK60312Anal fistula, simple, persistent
AddedK60313Anal fistula, simple, recurrent
AddedK60319Anal fistula, simple, unspecified
AddedK60321Anal fistula, complex, initial
AddedK60322Anal fistula, complex, persistent
AddedK60323Anal fistula, complex, recurrent
AddedK60329Anal fistula, complex, unspecified
DeletedK604Rectal fistula
AddedK6040Rectal fistula, unspecified
AddedK60411Rectal fistula, simple, initial
AddedK60412Rectal fistula, simple, persistent
AddedK60413Rectal fistula, simple, recurrent
AddedK60419Rectal fistula, simple, unspecified
AddedK60421
Rectal fistula, complex, initial
AddedK60422Rectal fistula, complex, persistent
AddedK60423Rectal fistula, complex, recurrent
AddedK60429Rectal fistula, complex, unspecified
Deleted
K605Anorectal fistula
AddedK6050Anorectal fistula, unspecified
AddedK60511Anorectal fistula, simple, initial
AddedK60512Anorectal fistula, simple, persistent
AddedK60513Anorectal fistula, simple, recurrent
AddedK60519Anorectal fistula, simple, unspecified
AddedK60521Anorectal fistula, complex, initial
AddedK60522Anorectal fistula, complex, persistent
AddedK60523Anorectal fistula, complex, recurrent
AddedK60529Anorectal fistula, complex, unspecified
DeletedL298Other pruritus
AddedL2981Cholestatic pruritus
AddedL2989Other pruritus
DeletedL661
Lichen planopilaris
AddedL6610Lichen planopilaris, unspecified
AddedL6611Classic lichen planopilaris
AddedL6612Frontal fibrosing alopecia
AddedL6619Other lichen planopilaris
DeletedL668Other cicatricial alopecia
AddedL6681Central centrifugal cicatricial alopecia
AddedL6689Other cicatricial alopecia
Deleted
M5136Other intervertebral disc degeneration, lumbar region
AddedM51360Other intervertebral disc degeneration, lumbar region with discogenic back pain only
AddedM51361Other intervertebral disc degeneration, lumbar region with lower extremity pain only
AddedM51362Other intervertebral disc degeneration, lumbar region with discogenic back pain and lower extremity pain
AddedM51369Other intervertebral disc degeneration, lumbar region without mention of lumbar back pain or lower extremity pain
Deleted
M5137Other intervertebral disc degeneration, lumbosacral region
AddedM51370Other intervertebral disc degeneration, lumbosacral region with discogenic back pain only
AddedM51371Other intervertebral disc degeneration, lumbosacral region with lower extremity pain only
Added M51372 Other intervertebral disc degeneration, lumbosacral region with discogenic back pain and lower extremity pain
Added M51379 Other intervertebral disc degeneration, lumbosacral region without mention of lumbar back pain or lower extremity pain
Added M6285 Dysfunction of the multifidus muscles, lumbar region
Deleted M659 Synovitis and tenosynovitis, unspecified
Added M6590 Unspecified synovitis and tenosynovitis, unspecified site
Added M65911 Unspecified synovitis and tenosynovitis, right shoulder
Added M65912 Unspecified synovitis and tenosynovitis, left shoulder
Added M65919 Unspecified synovitis and tenosynovitis, unspecified shoulder
Added M65921 Unspecified synovitis and tenosynovitis, right upper arm
Added M65922 Unspecified synovitis and tenosynovitis, left upper arm
Added M65929 Unspecified synovitis and tenosynovitis, unspecified upper arm
Added M65931 Unspecified synovitis and tenosynovitis, right forearm
Added M65932 Unspecified synovitis and tenosynovitis, left forearm
Added M65939 Unspecified synovitis and tenosynovitis, unspecified forearm
Added M65941 Unspecified synovitis and tenosynovitis, right hand
Added M65942 Unspecified synovitis and tenosynovitis, left hand
Added M65949 Unspecified synovitis and tenosynovitis, unspecified hand
Added M65951 Unspecified synovitis and tenosynovitis, right thigh
Added M65952 Unspecified synovitis and tenosynovitis, left thigh
Added M65959 Unspecified synovitis and tenosynovitis, unspecified thigh
Added M65961 Unspecified synovitis and tenosynovitis, right lower leg
Added M65962 Unspecified synovitis and tenosynovitis, left lower leg
Added M65969 Unspecified synovitis and tenosynovitis, unspecified lower leg
Added M65971 Unspecified synovitis and tenosynovitis, right ankle and foot
Added M65972 Unspecified synovitis and tenosynovitis, left ankle and foot
Added M65979 Unspecified synovitis and tenosynovitis, unspecified ankle and foot
Added M6598 Unspecified synovitis and tenosynovitis, other site
Added M6599 Unspecified synovitis and tenosynovitis, multiple sites
Revise from Q1381 Rieger's anomaly
Revise to Q1381 Rieger anomaly
Delete Q238 Other congenital malformations of aortic and mitral valves
Added Q2381 Bicuspid aortic valve
Added Q2382 Congenital mitral valve cleft leaflet
Added Q2388 Other congenital malformations of aortic and mitral valves
Added Q8786 Kleefstra syndrome
Added R4185 Anosognosia
Added T45AX1A Poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), initial encounter
Added T45AX1D Poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), subsequent encounter
Added T45AX1S Poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), sequela
Added T45AX2A Poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, initial encounter
Added T45AX2D Poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, subsequent encounter
Added T45AX2S Poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, sequela
Added T45AX3A Poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, initial encounter
Added T45AX3D Poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, subsequent encounter
Added T45AX3S Poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, sequela
Added T45AX4A Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, initial encounter
Added T45AX4D Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, subsequent encounter
Added T45AX4S Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, sequela
Added T45AX5A Adverse effect of immune checkpoint inhibitors and immunostimulant drugs, initial encounter
Added T45AX5D Adverse effect of immune checkpoint inhibitors and immunostimulant drugs, subsequent encounter
Added T45AX5S Adverse effect of immune checkpoint inhibitors and immunostimulant drugs, sequela
Added T45AX6A Underdosing of immune checkpoint inhibitors and immunostimulant drugs, initial encounter
Added T45AX6D Underdosing of immune checkpoint inhibitors and immunostimulant drugs, subsequent encounter
Added T45AX6S Underdosing of immune checkpoint inhibitors and immunostimulant drugs, sequela
Added T81320A Disruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, initial encounter
Added T81320D Disruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, subsequent encounter
Added T81320S Disruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, sequela
Added T81321A Disruption or dehiscence of closure of internal operation (surgical) would of abdominal wall muscle of fascia, initial encounter
Added T81321D Disruption or dehiscence of closure of internal operation (surgical) would of abdominal wall muscle of fascia, subsequent encounter
Added T81321S Disruption or dehiscence of closure of internal operation (surgical) would of abdominal wall muscle of fascia, sequela
Added T81328A Disruption or dehiscence of closure of other specified internal operation (surgical) wound, initial encounter
Added T81328D Disruption or dehiscence of closure of other specified internal operation (surgical) wound, subsequent encounter
Added T81328S Disruption or dehiscence of closure of other specified internal operation (surgical) wound, sequela
Added T81329A Deep disruption or dehiscence of operation wound, unspecified, initial encounter
Added T81329D Deep disruption or dehiscence of operation wound, unspecified, subsequent encounter
Added T81329S Deep disruption or dehiscence of operation wound, unspecified, sequela
Deleted T8132XA Disruption of internal operation (surgical) wound, not elsewhere classified, initial encounter
Deleted T8132XD Disruption of internal operation (surgical) wound, not elsewhere classified, subsequent encounter
Deleted T8132XS Disruption of internal operation (surgical) wound, not elsewhere classified, sequela
Added Z151 Genetic susceptibility to epilepsy and neurodevelopmental disorders
Added Z152 Genetic susceptibility to obesity
Added Z1721 Progesterone receptor positive status
Added Z1722 Progesterone receptor negative status
Added Z1731 Human epidermal growth factor receptor 2 positive status
Added Z1732 Human epidermal growth factor receptor 2 negative status
Added Z17410 Hormone receptor positive with human epidermal growth factor receptor 2 positive status
Added Z17411 Hormone receptor positive with human epidermal growth factor receptor 2 negative status
Added Z17420 Hormone receptor negative with human epidermal growth factor receptor 2 positive status
Added Z17421 Hormone receptor negative with human epidermal growth factor receptor 2 negative status
Added Z51A Encounter for sepsis aftercare
Deleted Z597 Insufficient social insurance and welfare support
Added Z5971 Insufficient health insurance coverage
Added Z5972 Insufficient welfare support
Added Z67A1 Duffy null
Added Z67A2 Duffy a positive
Added Z67A3 Duffy b positive
Added Z67A4 Duffy a and b positive
Revised from Z6854 Body mass index [BMI] pediatric, greater than or equal to 95th percentile for age
Revised to Z6854 Body mass index [BMI] pediatric,, 95th percentile for age to less than 120% of the 95th percentile for age
Added Z6855 Body mass index [BMI] pediatric, 120% of the 95th percentile for age to less than 140% of the 95th percentile for age
Added Z6856 Body mass index [BMI] pediatric, greater then or equal to 140% of the 95th percentile for age
Added Z8372 Family history of familial adenomatous polyposis
Deleted Z86010 Personal history of colonic polyps
Added Z860100 Personal history of colon polyps, unspecified
Added Z860101 Personal history of adenomatous and serrated colon polyps
Added Z860102 Personal history of hyperplastic colon polyps
Added Z860109 Personal history of other colon polyps
Added Z9226 Personal history of immune checkpoint inhibitor therapy
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